Aim. To study quality of life, anxiety, awareness and treatment compliance in patients with myocardial infarction before and after the educational program on secondary prevention.Materials and Methods. The prospective study included 132 patients (mean age 60.6 ± 1.8 years) who were on outpatient follow-up after myocardial infarction. Using an original questionnaire, we interviewed all patients about their anxiety, quality of life, and compliance before and after the educational program on secondary prevention. Results. Initially, the patients with myocardial infarction had a high level of anxiety, low mental and physical quality of life, and an insufficient level of compliance and awareness of secondary prevention issues. One-month educational program significantly improved all these indicators.Conclusions. The educational program on secondary prevention after myocardial infarction is justified.