BACKGROUND: Occupational Health and Safety (OHS) training is a crucial component of workplace safety. In recent years, Cross-reality (XR) has emerged as a viable path for immersive and successful training experiences. This paper presents preliminary results from the SCISSOR project, a groundbreaking initiative exploring the potential of XR technologies in enhancing OHS training, especially in healthcare setting regarding ionization radiation exposure. MATERIALS AND METHODS: This quasi-experimental pilot study consisted of several stages from July 2021 to June 2022. Phase 1 consists of the realization of the virtual scenario, Phase 2 in XR setting up and laboratory simulation, and lastly, and Phase 3 based on the on field testing. RESULTS: About 60 participants, including students and researchers, participated in Phases 1 and 2 preliminary testing and 9 healthcare workers (HCWs) in Phase 3. Phase 1 involved the 3D reconstruction of a real-life scenario using digital photogrammetry. These models were then utilized to recreate the operating room scenario and program interactions with the equipment. In Phase 2, the overall appreciation for the level of realism, comfort, and usability of the application was investigated. The test results demonstrated a general appreciation for the application and its effectiveness. Phase 3, concerning field tests, involved HCWs. The results suggest that XR technologies hold significant promise in revolutionizing OHS training, offering a more engaging, effective, and adaptable approach to workplace safety education. CONCLUSION: The SCISSOR project’s initial findings underscore the potential of XR as a transformative tool in OHS training, ultimately contributing to safer workplaces, reduced accidents, and enhanced overall employee well-being.