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Zdravniški Vestnik
Article . 2022 . Peer-reviewed
License: CC BY NC
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Zdravniški Vestnik
Article . 2023
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Toksični učinki kokaina na srčnožilni sistem in obravnava bolnikov z bolečino v prsih zaradi zlorabe kokaina

Authors: Mark Jovanović; Miran Brvar;

Toksični učinki kokaina na srčnožilni sistem in obravnava bolnikov z bolečino v prsih zaradi zlorabe kokaina

Abstract

V zadnjih 10 letih beležimo porast zlorabe kokaina v številnih državah zahodne in osrednje Evrope, tudi v Sloveniji. Zloraba kokaina je pomemben dejavnik tveganja za razvoj srčnožilnih bolezni, ki jih glede na čas izpostavljenosti kokainu razdelimo na akutne in kronične. Ocenjuje se, da približno 40 % uporabnikov kokaina vsaj enkrat doživi angino pektoris zaradi zlorabe kokaina, 6 % teh bolnikov pa razvije miokardni infarkt. V klinični praksi algoritem obravnave bolnikov z akutno bolečino v prsih zaradi zlorabe kokaina ni poenoten, zato se zdravljenje teh bolnikov pomembno razlikuje od kontrolne skupine bolnikov z akutno prsno bolečino, ki ni posledica zlorabe kokaina. Tako se pri vsakdanjem kliničnem delu zastavljajo številna vprašanja glede varnosti in koristi zdravljenja z zaviralci receptorjev beta pri bolnikih z akutno prsno bolečino zaradi zlorabe kokaina. Prepoznati zlorabo kokaina je pomembno pri tistih bolnikih s prsno bolečino, ki potrebujejo dvotirno protitrombotično zdravljenje po perkutanem koronarnem posegu z vstavitvijo žilne opornice, saj je pri uporabnikih kokaina zaradi nizke adherence povečano tveganje za trombozo žilne opornice. Prav tako ni popolnoma jasno, kateri dejavniki povečajo tveganje za možgansko krvavitev zaradi zlorabe kokaina, kar je potrebno upoštevati pred uvedbo protitrombotičnega zdravljenja. Vse to je sprožilo pobudo po prenovi smernic Ameriškega združenja za srce oz. izdelavi priporočil Evropskega združenja za kardiologijo, ki bodo standardizirale obravnavo bolnikov z akutno bolečino v prsih zaradi zlorabe kokaina, tudi v Sloveniji.

Keywords

miokardni infarkt, angina pektoris, kokain, kardiotoksičnost, R, Medicine, zdravljenje

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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