descriptionPublicationkeyboard_double_arrow_right Article 02 Jul 2009 English Publisher:WileyJournal:Liver International, volume 29, pages 955-965 (issn: 1478-3223, eissn: 1478-3231,

Authors: Lee, TKW; Ng, IOL; Ma, S; Castilho, A;

doi: 10.1111/j.1478-3231.2009.02040.x

pmid: 19490415

handle: 10722/88508

Liver cancer stem cells: implications for a new therapeutic target

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Abstract

AbstractHepatocellular carcinoma (HCC) is an aggressive tumour with a poor prognosis. Current therapeutic strategies against this disease target mostly rapidly growing differentiated tumour cells. However, the result is often dismal due to the chemoresistant nature of this tumour type. Recent research efforts on stem cells and cancer biology have shed light on new directions for the eradication of cancer stem cells (CSCs) in HCC. The liver is a distinctive organ with the ability of tissue renewal in response to injury. Based on the hypothesis that cancer development is derived from the hierarchy of the stem cell system, we will briefly discuss the origin of liver stem cells and its relation to HCC development. We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease.

Related Organizations

Queen Mary Hospital
China (People's Republic of)
University of Hong Kong
China (People's Republic of)
University of Hong Kong (香港大學)
China (People's Republic of)
Li Ka Shing Faculty of Medicine, University of Hong Kong
Hong Kong
Hospital Authority
China (People's Republic of)

Keywords

Carcinoma, Hepatocellular, Liver Neoplasms - drug therapy - metabolism - pathology, 610, Antineoplastic Agents, Carcinoma, Hepatocellular - drug therapy - metabolism - pathology, Hepatocytes - drug effects - metabolism - pathology, Biomarkers, Tumor, Animals, Humans, Stem Cells - drug effects - metabolism - pathology, Neoplastic Stem Cells - drug effects - metabolism - pathology, Tumor Markers, Cell Proliferation, Stem Cells, Carcinoma, Liver Neoplasms, Cell Differentiation, Hepatocellular - drug therapy - metabolism - pathology, Liver Regeneration, Biological - metabolism, Liver, Liver - drug effects - metabolism - pathology, Drug Design, Hepatocytes, Neoplastic Stem Cells, Antineoplastic Agents - therapeutic use, Tumor Markers, Biological - metabolism, Signal Transduction

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