Objective: The purpose of the opinions presented in this paper is to update promising models of implementation of anti-corruption measures and procedures with respect to investment and foreign economic activity that are implemented in regional policy format. The methods that served as the basis for the contents and conclusions presented by the author are contained in the general means of cognition: systemic approach, comparative law analysis, hypotheses testing. The academic novelty of this paper consists in a comprehensive consideration of a specific research subject, that is, prevention of manifestations of corruption using general and specialised prevention means with a view to safeguard the investment attractiveness of regional economy (as illustrated by the example of the Republic of Tatarstan). The practical significance of the paper is determined in its resolution part where scientifically grounded recommendations on the organisation of the prevention of manifestations of corruption based on a package of measures are set forth, among them: ensuring the quality of normative law regulation of the activities of subjects of investment operations, special anti-corruption awareness raising for law enforcement officials from amongst public functionaries, forming and implementing principles of due diligence in interacting with contracting parties which allows to avoid manifestations of corruption and their adverse consequences.