Elevated Aβ aggregates in feces from Alzheimer’s disease patients: a proof-of-concept study
Copyright policy )Elevated Aβ aggregates in feces from Alzheimer’s disease patients: a proof-of-concept study
Abstract Background Misfolding and aggregation of amyloid β (Aβ), along with neurofibrillary tangles consisting of aggregated Tau species, are pathological hallmarks of Alzheimer’s disease (AD) onset and progression. In this study, we hypothesized the clearance of Aβ aggregates from the brain and body into the gut. Methods To investigate this, we used surface-based fluorescence intensity distribution analysis (sFIDA) to determine the Aβ aggregate concentrations in feces from 26 AD patients and 31 healthy controls (HC). Results Aβ aggregates were detectable in human feces and their concentrations were elevated in AD patients compared to HC (specificity 90.3%, sensitivity 53.8%). Conclusion Thus, fecal Aβ aggregates constitute a non-invasive biomarker candidate for diagnosing AD. Whether digestion-resistant Aβ aggregates in feces are secreted via the liver and bile or directly from the enteric neuronal system remains to be elucidated.
- Heinrich Heine University Düsseldorf Germany
- Helmholtz Association of German Research Centres Germany
- Forschungszentrum Jülich Germany
- University of Cologne Germany
- University Hospital Cologne Germany
Fecal/stool samples, Male, 610, Neurosciences. Biological psychiatry. Neuropsychiatry, Proof of Concept Study, Feces, Protein Aggregates, Alzheimer Disease, Humans, RC346-429, info:eu-repo/classification/ddc/610, Aged, Aged, 80 and over, Amyloid beta-Peptides, Research, Female [MeSH] ; Aged, 80 and over [MeSH] ; Aged [MeSH] ; Protein Aggregates [MeSH] ; Amyloid beta-Peptides/metabolism [MeSH] ; Humans [MeSH] ; Clearance ; Middle Aged [MeSH] ; Male [MeSH] ; Feces/chemistry [MeSH] ; Amyloidosis ; Research ; Biomarkers/metabolism [MeSH] ; Brain-gut-microbiota axis ; sFIDA ; Alzheimer Disease/metabolism [MeSH] ; Aβ oligomer quantitation ; Leaky gut ; Proof of Concept Study [MeSH] ; Alzheimer Disease/pathology [MeSH] ; Fecal/stool samples, sFIDA, Amyloidosis, Middle Aged, Aβ oligomer quantitation, Leaky gut, Brain-gut-microbiota axis, Female, Neurology. Diseases of the nervous system, Biomarkers, RC321-571
Fecal/stool samples, Male, 610, Neurosciences. Biological psychiatry. Neuropsychiatry, Proof of Concept Study, Feces, Protein Aggregates, Alzheimer Disease, Humans, RC346-429, info:eu-repo/classification/ddc/610, Aged, Aged, 80 and over, Amyloid beta-Peptides, Research, Female [MeSH] ; Aged, 80 and over [MeSH] ; Aged [MeSH] ; Protein Aggregates [MeSH] ; Amyloid beta-Peptides/metabolism [MeSH] ; Humans [MeSH] ; Clearance ; Middle Aged [MeSH] ; Male [MeSH] ; Feces/chemistry [MeSH] ; Amyloidosis ; Research ; Biomarkers/metabolism [MeSH] ; Brain-gut-microbiota axis ; sFIDA ; Alzheimer Disease/metabolism [MeSH] ; Aβ oligomer quantitation ; Leaky gut ; Proof of Concept Study [MeSH] ; Alzheimer Disease/pathology [MeSH] ; Fecal/stool samples, sFIDA, Amyloidosis, Middle Aged, Aβ oligomer quantitation, Leaky gut, Brain-gut-microbiota axis, Female, Neurology. Diseases of the nervous system, Biomarkers, RC321-571
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