The analysis of the foreign economic restrictions of the Russian Federation, which have a multi-level impact on the Russian economy under the conditions of sanctions pressure, is carried out. The key challenges and opportunities arising from sanctions regimes, as well as ways of digital transformation of business and the national economy are considered. The importance of digitalization and the introduction of innovations as factors of increasing competitiveness and resilience to external influences are emphasized. Examples of successful application of digital technologies in various sectors of the economy are given, with an emphasis on their role in overcoming sanctions barriers. In addition, the mechanisms of adaptation and structural transformations aimed at reducing dependence on external economic factors, strengthening the domestic market and developing domestic technological solutions are revealed.