Menopausal and postmenopausal disorders represent a signiашcant problem in women of working age and considerably reduce the quality of life. Current treatment of these diseases includes the use of hormonal drugs, vitamins, minerals, drugs improving cerebral circulation, homeopathic remedies, hypotensive agents, tranquilizers, antidepressants, and sleeping pills, most of which have a number of major side effects. Clinical studies demonstrated insufficient safety of a long-term hormone replacement therapy; hence, the screening of alternative treatment methods is rapidly ongoing. Medicinal plants are a rich source of bioactive substances, and herbal medicine (phytotherapy) was proposed as a promising approach to treat menopausal and postmenopausal disorders. Of note, molecular weight and structure of phytoestrogens are similar to those of endogenous estrogens, enabling the former to bind to human estrogen receptors and activate respective signaling pathways.