Transformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: clinicopathologic features and clonal relationship
Copyright policy )Transformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: clinicopathologic features and clonal relationship
A patient with fibrosing alveolitis developed a diffuse large B-cell (DLBC) lymphoma that expressed CD20 and CD30. After an initial response, the lymphoma relapsed and was salvaged with further chemotherapy. After another remission of 3 years, a pre-B-cell acute lymphoblastic leukemia (ALL), which expressed CD10, CD19, CD22, CD79a, CD34 and terminal deoxyribonucleotidyl transferase, developed and led to death. Molecular analysis of the immunoglobulin heavy-chain gene showed that the initial lymphoma and its relapse were clonally related. At leukemic relapse, 2 clones related to the initial and relapsed lymphoma clones were present. DLBC lymphomas arise from post-follicle center B cells, whereas ALL arises from pregerminal B cells. Therefore, a direct transformation of DLBC lymphoma to ALL appears unlikely. The overall features suggest instead separate lymphoma and leukemic evolution from a common mutated B-cell precursor rather than transformation of DLBC lymphoma to ALL.
- Queen Mary University of London United Kingdom
- University of Hong Kong (香港大學) China (People's Republic of)
- Hospital Authority China (People's Republic of)
- University of Hong Kong China (People's Republic of)
- Queen Mary Hospital China (People's Republic of)
Neoplastic - genetics - pathology, Epstein-Barr virus-expressed RNA, Lymphoma, polymerase chain reaction, clonal evolution, Lymphoma, Large B-Cell, Diffuse - drug therapy - genetics - pathology, Cell Transformation, Fatal Outcome, Neoplasms, Ribosomal Proteins - analysis, Antineoplastic Combined Chemotherapy Protocols, Neoplasm - analysis, RNA, Neoplasm, In Situ Hybridization, DLBC, RNA-Binding Proteins, Neoplasms, Second Primary, DNA, Neoplasm, DNA, Neoplasm - analysis, Burkitt Lymphoma, Second Primary, PCR, Cell Transformation, Neoplastic, RNA, Viral, Female, Lymphoma, Large B-Cell, Diffuse, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Lymphoma, B-Cell, Viral - analysis, 572, IgH, Molecular Sequence Data, diffuse large B-cell lymphoma, RNA-Binding Proteins - analysis, acute lymphoblastic leukemia, Immunophenotyping, B-Cell - drug therapy - genetics - pathology, Diffuse - drug therapy - genetics - pathology, Large B-Cell, Humans, Tdt, Aged, EBER, Base Sequence, immunoglobulin heavy chain, RNA, Viral - analysis, Lymphoma, B-Cell - drug therapy - genetics - pathology, DNA, Clone Cells, Burkitt Lymphoma - drug therapy - genetics - pathology, Karyotyping, RNA, RNA, Neoplasm - analysis, Cell Transformation, Neoplastic - genetics - pathology, ALL
Neoplastic - genetics - pathology, Epstein-Barr virus-expressed RNA, Lymphoma, polymerase chain reaction, clonal evolution, Lymphoma, Large B-Cell, Diffuse - drug therapy - genetics - pathology, Cell Transformation, Fatal Outcome, Neoplasms, Ribosomal Proteins - analysis, Antineoplastic Combined Chemotherapy Protocols, Neoplasm - analysis, RNA, Neoplasm, In Situ Hybridization, DLBC, RNA-Binding Proteins, Neoplasms, Second Primary, DNA, Neoplasm, DNA, Neoplasm - analysis, Burkitt Lymphoma, Second Primary, PCR, Cell Transformation, Neoplastic, RNA, Viral, Female, Lymphoma, Large B-Cell, Diffuse, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Lymphoma, B-Cell, Viral - analysis, 572, IgH, Molecular Sequence Data, diffuse large B-cell lymphoma, RNA-Binding Proteins - analysis, acute lymphoblastic leukemia, Immunophenotyping, B-Cell - drug therapy - genetics - pathology, Diffuse - drug therapy - genetics - pathology, Large B-Cell, Humans, Tdt, Aged, EBER, Base Sequence, immunoglobulin heavy chain, RNA, Viral - analysis, Lymphoma, B-Cell - drug therapy - genetics - pathology, DNA, Clone Cells, Burkitt Lymphoma - drug therapy - genetics - pathology, Karyotyping, RNA, RNA, Neoplasm - analysis, Cell Transformation, Neoplastic - genetics - pathology, ALL
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).12 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!