While ex vivo liver resection combined with autotransplantation has been reported from various perspectives, the use of fast-track protocols for this procedure in treating end-stage hepatic alveolar echinococcosis has not been documented.We retrospectively analyzed the outcomes of 21 patients with end-stage hepatic alveolar echinococcosis who underwent ex vivo liver resection and autotransplantation, followed by a fast-track recovery protocol at our institution between 2014 and 2017.All patients successfully underwent liver autotransplantation with no intraoperative mortality. Postoperative hospital stays ranged from 4 to 51 days, with an average of 23.5 days. Hospital costs averaged $3 million (range $1.94-4.07 million). Twelve patients experienced postoperative complications, with four classified as Clavien-Dindo grade III or higher. Two patients died due to intra-abdominal bleeding and acute cerebral hemorrhage, respectively. Nineteen patients were followed for a median of 16.2 months (range 3-38 months), with no recurrence of hepatic alveolar echinococcosis.Fast-track protocols are safe and effective in the context of ex vivo liver resection and autotransplantation.