Downloads provided by UsageCountsA first update on mapping the human genetic architecture of COVID-19
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COVID-19 Host Genetics Initiative, ; Pathak, GA; Karjalainen, J; Stevens, C; Neale, BM; Daly, M; Ganna, A; +193 Authors
COVID-19 Host Genetics Initiative, ; Pathak, GA; Karjalainen, J; Stevens, C; Neale, BM; Daly, M; Ganna, A; Andrews, SJ; Kanai, M; Cordioli, M; Polimanti, R; Harerimana, N; Pirinen, M; Liao, RG; Chwialkowska, K; Trankiem, A; Balaconis, MK; Nguyen, H; Solomonson, M; Veerapen, K; Wolford, B; Roberts, G; Park, D; Ball, CA; Coignet, M; McCurdy, S; Knight, S; Partha, R; Rhead, B; Zhang, M; Berkowitz, N; Gaddis, M; Noto, K; Ruiz, L; Pavlovic, M; Hong, EL; Rand, K; Girshick, A; Guturu, H; Baltzell, AH; Niemi, MEK; Rahmouni, S; Guntz, J; Beguin, Y; Cordioli, M; Pigazzini, S; Nkambule, L; Georges, M; Moutschen, M; Misset, B; Darcis, G; Guiot, J; Azarzar, S; Gofflot, S; Claassen, S; Malaise, O; Huynen, P; Meuris, C; Thys, M; Jacques, J; Leonard, P; Frippiat, F; Giot, J-B; Sauvage, A-S; Frenckell, CV; Belhaj, Y; Lambermont, B; Nakanishi, T; Morrison, DR; Mooser, V; Richards, JB; Butler-Laporte, G; Forgetta, V; Li, R; Ghosh, B; Laurent, L; Belisle, A; Henry, D; Abdullah, T; Adeleye, O; Mamlouk, N; Kimchi, N; Afrasiabi, Z; Rezk, N; Vulesevic, B; Bouab, M; Guzman, C; Petitjean, L; Tselios, C; Xue, X; Afilalo, J; Afilalo, M; Oliveira, M; Brenner, B; Brassard, N; Durand, M; Schurr, E; Lepage, P; Ragoussis, J; Auld, D; Chassé, M; Kaufmann, DE; Lathrop, GM; Adra, D; Hayward, C; Glessner, JT; Shaw, DM; Campbell, A; Morris, M; Hakonarson, H; Porteous, DJ; Below, J; Richmond, A; Chang, X; Polikowski, H; Lauren, PE; Chen, H-H; Wanying, Z; Fawns-Ritchie, C; North, K; McCormick, JB; Chang, X; Glessner, JR; Hakonarson, H; Gignoux, CR; Wicks, SJ; Crooks, K; Barnes, KC; Daya, M; Shortt, J; Rafaels, N; Chavan, S; Timmers, PRHJ; Wilson, JF; Tenesa, A; Kerr, SM; D’Mellow, K; Shahin, D; El-Sherbiny, YM; von Hohenstaufen, KA; Sobh, A; Eltoukhy, MM; Nkambul, L; Elhadidy, TA; Abd Elghafar, MS; El-Jawhari, JJ; Mohamed, AAS; Elnagdy, MH; Samir, A; Abdel-Aziz, M; Khafaga, WT; El-Lawaty, WM; Torky, MS; El-shanshory, MR; Yassen, AM; Hegazy, MAF; Okasha, K; Eid, MA; Moahmed, HS; Medina-Gomez, C; Ikram, MA; Uitterlinden, AG; Mägi, R; Milani, L; Metspalu, A; Laisk, T; Läll, K; Lepamets, M; Esko, T; Reimann, E; Naaber, P; Laane, E; Pesukova, J; Peterson, P; Kisand, K; Tabri, J; Allos, R; Hensen, K; Starkopf, J; Ringmets, I; Tamm, A; Kallaste, A; Alavere, H; Metsalu, K; Puusepp, M; Batini, C; Tobin, MD; Venn, LD; Lee, PH; Shrine, N; Williams, AT; Guyatt, AL; John, C; Packer, RJ; Ali, A; Free, RC; Wang, X; Wain, LV; Hollox, EJ; Bee, CE;
10261/288052 , 2117/371635 , 11588/913567 , 1871.1/2b8b46b3-6364-409e-a505-0f32f0f4169b , 11370/00125da7-04c5-43a5-89fb-12f7d70d782f , 2268/294295 , 11365/1220799 , 10807/234173 , 20.500.11820/035ea0f3-fe8f-4af1-8b45-efb1c1b1b83d , 11577/3478043 , 11379/562656 , 11380/1289206 , 11391/1588534 , 11697/207439 , 11585/917519 , 11571/1477361
10261/288052 , 2117/371635 , 11588/913567 , 1871.1/2b8b46b3-6364-409e-a505-0f32f0f4169b , 11370/00125da7-04c5-43a5-89fb-12f7d70d782f , 2268/294295 , 11365/1220799 , 10807/234173 , 20.500.11820/035ea0f3-fe8f-4af1-8b45-efb1c1b1b83d , 11577/3478043 , 11379/562656 , 11380/1289206 , 11391/1588534 , 11697/207439 , 11585/917519 , 11571/1477361
A first update on mapping the human genetic architecture of COVID-19
The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1 . Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2 . Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity
Peer reviewed
- Northamptonshire Healthcare NHS Foundation Trust United Kingdom
- University of Genoa Italy
- Cambridge University Hospitals NHS Foundation Trust United Kingdom
- UNIVERSITE COTE D'AZUR France
- University of Oxford United Kingdom
:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Human Genetic, Quantitative Trait Loci, MUC5B PROMOTER POLYMORPHISM, Sciences de la santé humaine, Immunologie & maladie infectieuse, Genome-wide association studies, COVID-19 (Malaltia), whole exam sequencing, Medical Genetics and Genomics, UFSP13-7 Evolution in Action: From Genomes to Ecosystems, COVID-19; genetics, name=General, COVID-19 (Disease), SDG 3 - Good Health and Well-being, Matters Arising, Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica, /dk/atira/pure/subjectarea/asjc/1000, Humans, Immunology & infectious disease, Genetic variation, Human health sciences, Genomes, muc5b promoter polymorphism; Science & Technology - Other Topics, Medicinsk genetik, 1000 Multidisciplinary, covid genetics, COVID-19, Chromosome Mapping, Human Genetics, 10124 Institute of Molecular Life Sciences, Medicinsk genetik och genomik, covid-19, 570 Life sciences; biology, Chromosome Mapping; Human Genetics; Humans; Quantitative Trait Loci; COVID-19, Medical Genetics, Human
:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Human Genetic, Quantitative Trait Loci, MUC5B PROMOTER POLYMORPHISM, Sciences de la santé humaine, Immunologie & maladie infectieuse, Genome-wide association studies, COVID-19 (Malaltia), whole exam sequencing, Medical Genetics and Genomics, UFSP13-7 Evolution in Action: From Genomes to Ecosystems, COVID-19; genetics, name=General, COVID-19 (Disease), SDG 3 - Good Health and Well-being, Matters Arising, Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica, /dk/atira/pure/subjectarea/asjc/1000, Humans, Immunology & infectious disease, Genetic variation, Human health sciences, Genomes, muc5b promoter polymorphism; Science & Technology - Other Topics, Medicinsk genetik, 1000 Multidisciplinary, covid genetics, COVID-19, Chromosome Mapping, Human Genetics, 10124 Institute of Molecular Life Sciences, Medicinsk genetik och genomik, covid-19, 570 Life sciences; biology, Chromosome Mapping; Human Genetics; Humans; Quantitative Trait Loci; COVID-19, Medical Genetics, Human
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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