Studies showed that COVID-19-related fear and anxiety were correlated with varying psychological issues such as depressive and anxiety disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and generalized anxiety disorder. This systematic review and meta-analysis aim to estimate the pooled raw mean of COVID-19-related fear and anxiety. The second purpose of this study is to clarify the role of potential moderators in COVID-19-related fear and anxiety. For these reasons, the studies were searched in various databases (e.g., Google Scholar, PubMed, Web of Science, and SCOPUS). The study’s findings revealed that the pooled mean of fear of COVID-19 was 18.96, and the pooled mean of 2.50 was for COVID-19 anxiety. Moderator analyses revealed that culture and continent were significant moderators for COVID-19-related fear; continent and target population for COVID-19-related anxiety. Meta-regression analyses found that none of the continuous moderators (i.e., age and female proportion) were significant predictors of COVID-19-related fear and anxiety.