Bringing diffuse X-ray scattering into focus
Copyright policy )Bringing diffuse X-ray scattering into focus
AbstractX-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail.
- Los Alamos National Laboratory United States
- Department of Bioengineering and Therapeutic Sciences University of California, San Francisco United States
- University of California San Francisco United States
- SUNY at Buffalo United States
- University of California, San Francisco United States
Models, Molecular, Protein Conformation, Biophysics, 0601 Biochemistry and Cell Biology (for), Bioengineering, Molecular Dynamics Simulation, Proteins (mesh), 0304 Medicinal and Biomolecular Chemistry (for), Article, X-Ray Diffraction: methods, Molecular Dynamics Simulation (mesh), Scattering, Medicinal and Biomolecular Chemistry, X-Ray Diffraction (mesh), X-Ray Diffraction, Models, Radiation (mesh), Scattering, Radiation, 3101 Biochemistry and cell biology (for-2020), Proteins: chemistry, Protein Conformation (mesh), Radiation, 31 Biological Sciences (for-2020), X-Rays, Generic health relevance (hrcs-hc), Bioengineering (rcdc), Molecular, Proteins, Biological Sciences, 540, 3101 Biochemistry and Cell Biology (for-2020), Molecular (mesh), Biochemistry and Cell Biology, Generic health relevance, Biophysics (science-metrix), X-Rays (mesh)
Models, Molecular, Protein Conformation, Biophysics, 0601 Biochemistry and Cell Biology (for), Bioengineering, Molecular Dynamics Simulation, Proteins (mesh), 0304 Medicinal and Biomolecular Chemistry (for), Article, X-Ray Diffraction: methods, Molecular Dynamics Simulation (mesh), Scattering, Medicinal and Biomolecular Chemistry, X-Ray Diffraction (mesh), X-Ray Diffraction, Models, Radiation (mesh), Scattering, Radiation, 3101 Biochemistry and cell biology (for-2020), Proteins: chemistry, Protein Conformation (mesh), Radiation, 31 Biological Sciences (for-2020), X-Rays, Generic health relevance (hrcs-hc), Bioengineering (rcdc), Molecular, Proteins, Biological Sciences, 540, 3101 Biochemistry and Cell Biology (for-2020), Molecular (mesh), Biochemistry and Cell Biology, Generic health relevance, Biophysics (science-metrix), X-Rays (mesh)
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