descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2001 English Publisher:Elsevier BVJournal:Vaccine, volume 19, pages 4,219-4,225 (issn: 0264-410X,

Authors: Chan, KW; Yuen, KY; Yao, X; Wen, YM; Zheng, B; Ng, MH; He, LF;

doi: 10.1016/s0264-410x(01)00158-x

pmid: 11457548

handle: 10722/148265

Therapeutic efficacy of hepatitis B surface antigen–antibodies-recombinant DNA composite in HBsAg transgenic mice

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Abstract

Therapeutic efficacy of HBsAg-anti-HBs-recombinant DNA harboring hepatitis B virus (HBV) S gene complex was compared with three other therapeutic vaccine candidates (recombinant HBsAg, HBsAg complexed to anti-HBs antibodies and naked plasmid DNA encoding the HBV S gene). After four injections at 3-week intervals, the most pronounced decrease of serum HBsAg, the highest titer of anti-HBs response, the highest level of interferon-gamma produced by splenocytes and potent cytotoxicity T cell response were observed in the HBsAg-anti HBs-sDNA immunized group. Reduced expression of HBsAg in hepatocytes was also shown. The therapeutic mechanism of HBsAg-anti-HBs-DNA was speculated as modulation of HBsAg presentation via both endogenous and exogenous pathways.

Related Organizations

University of Hong Kong
China (People's Republic of)
University of Hong Kong (香港大學)
China (People's Republic of)
Shanghai University
China (People's Republic of)
Shanghai Medical College of Fudan University
China (People's Republic of)
Fudan University
China (People's Republic of)

Keywords

Cytokines - Biosynthesis, Hepatitis B virus, Dna, Recombinant - Immunology, T-Lymphocytes, Cytotoxic - Immunology, DNA, Recombinant, Mice, Transgenic, Antigen-Antibody Complex, Inbred C57bl, Hepatitis B Surface Antigens - Blood - Immunology, Transgenic, Mice, Recombinant - Immunology, Animals, Hepatitis B Vaccines, Hepatitis B - Therapy, Hepatitis B Antibodies, T-Lymphocytes, Cytotoxic - Immunology, Hepatitis B Surface Antigens, Immune tolerance, Dna, Therapeutic vaccine, Hepatitis B, Mice, Inbred C57bl, Antigen-Antibody Complex - Immunology, Mice, Inbred C57BL, Hepatitis B Vaccines - Therapeutic Use, Hepatitis B Antibodies - Immunology, Liver - Pathology - Virology, Liver, Cytokines, T-Lymphocytes, Cytotoxic

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