To study the interference of changes in the level of brain natriuretic propeptide (NT-proBNP) with stable angina (TTFS) depending on changes in the levels of uric acid (UA) in the assessment of the functional state of the myocardium and coronary flow reserve with improved prediction of the disease 120 patients were examined diagnosed with TTFS. It determined that UA can be used as a biomarker of coronary and functional reserve, since the dynamics of this parameter has predictive value for reducing the size and regression of left ventricular hypertrophy (LV) systolic function improvement, as well as to increase the coronary flow reserve. Even with preserved systolic LV function with normal values of LVEF, and regardless of the severity of clinical manifestations of heart failure, NT-proBNP has a predicative value to reduce the size and severity of regression of LV hypertrophy and increase in coronary flow reserve. Considering a predictive value for progression of dyslipidemia, coronary reserve changes and the functional status of patients with TTFS, UA, NTproBNP and CRP can be used as biomarkers of susceptibility to therapy and patient selection for an intensification of medical treatment, as well as for interventional procedures.