Objective: This study aimed to assess the association between women’s platelet indices and bone mineral density to evaluate osteoporosis, which has a significant impact on quality of life throughout the postmenopausal age. Materials and Methods: The study was retrospectively designed, and data from 316 postmenopausal patients who applied to the obstetrics and gynecology outpatient clinic between January 2021 and January 2023, underwent bone mineral density measurements during follow-up, and met the inclusion and exclusion criteria were obtained. The data were evaluated in 3 groups as normal, osteopenia, and osteoporosis according to bone mineral density. Platelet indices, age, body mass index (BMI), and bone mineral density were compared with platelet indices in the hemogram results of the patients on the same day. Results: The mean ages of the osteoporosis, osteopenia, and normal groups were 61.4, 58.4, and 56.2 years, respectively. The mean weight was 72.9 kg in the osteoporosis group, 74.09 kg in the osteopenia group, and 79.4 kg in the normal group. When the groups were compared, no significant difference was observed between age, platelet count, platelet distribution width, mean platelet volume (MPV), platelet-large cell ratio, and thrombocytocrit but a significant difference was found between the osteoporosis and normal groups in terms of BMI (p=0.027). Conclusion: Although numerous studies in the literature have demonstrated a connection between osteoporosis and MPV and platelet count, our investigation revealed no such association and showed that the risk of osteoporosis decreased as BMI increased.