The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN
Copyright policy )The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN
Key Points INCB053914 and ruxolitinib synergize to induce apoptosis of JAK2V617F-driven cells and to inhibit neoplastic growth of primary MPN cells. INCB053914 antagonizes ruxolitinib persistence in an in vivo MPN model.
- Moffitt Cancer Center United States
- Incyte (United States) United States
Myeloproliferative Disorders, Dose-Response Relationship, Drug, Specialties of internal medicine, Drug Synergism, Mechanistic Target of Rapamycin Complex 1, Disease Models, Animal, Mice, Pyrimidines, RC581-951, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Nitriles, Neoplastic Stem Cells, Animals, Heterografts, Humans, Janus Kinase Inhibitors, Pyrazoles, Protein Kinase Inhibitors, Cell Proliferation, Signal Transduction
Myeloproliferative Disorders, Dose-Response Relationship, Drug, Specialties of internal medicine, Drug Synergism, Mechanistic Target of Rapamycin Complex 1, Disease Models, Animal, Mice, Pyrimidines, RC581-951, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Nitriles, Neoplastic Stem Cells, Animals, Heterografts, Humans, Janus Kinase Inhibitors, Pyrazoles, Protein Kinase Inhibitors, Cell Proliferation, Signal Transduction
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