Integrated analysis of methylome and transcriptome responses to exercise training in children with overweight/obesity
Copyright policy )Integrated analysis of methylome and transcriptome responses to exercise training in children with overweight/obesity
This study pioneers the exploration into the effects of exercise on whole blood genome-wide DNA methylation patterns and its association with changes in transcriptome profiles in children with overweight/obesity. Exercise potentially impacts molecular pathways involved in metabolism and immune functions in children with overweight/obesity (sex-specific responses) through the modification of epigenetic and transcriptomic profiles. Our preliminary results provide initial steps to understand better the molecular mechanisms underlying cardiometabolic benefits of exercise in children with overweight/obesity.
- University of Granada Spain
- University of California, Irvine United States
- Karolinska Institute Sweden
- Karolinska University Hospital Sweden
- Institució dels Centres de Recerca de Catalunya Spain
Male, Pediatric Obesity, pediatrics, lastentautioppi, Omics, lapset (ikäryhmät), methylome, Methylation, Pediatrics, Epigenesis, Genetic, Epigenome, Humans, geeniekspressio, Obesity, Child, Exercise, epigenetics, Gene Expression Profiling, ylipaino, DNA Methylation, Overweight, omics, DNA-metylaatio, epigenetiikka, gene expression, Epigenetics, Female, CpG Islands, methylation, transkriptomi, Gene expression, RNA-seq, RNA-sekvensointi, Transcriptome, transcriptome, liikuntahoito
Male, Pediatric Obesity, pediatrics, lastentautioppi, Omics, lapset (ikäryhmät), methylome, Methylation, Pediatrics, Epigenesis, Genetic, Epigenome, Humans, geeniekspressio, Obesity, Child, Exercise, epigenetics, Gene Expression Profiling, ylipaino, DNA Methylation, Overweight, omics, DNA-metylaatio, epigenetiikka, gene expression, Epigenetics, Female, CpG Islands, methylation, transkriptomi, Gene expression, RNA-seq, RNA-sekvensointi, Transcriptome, transcriptome, liikuntahoito
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