This research work studies the structural phase parameters and physicomechanical properties of metal-matrix composite materials based on a Ni–TiB2 system obtained by additive manufacturing (specifically, direct laser deposition). The properties of the composites obtained were investigated at high temperatures (up to 1000 °C). The feasibility of the fabrication of a composite nanostructure of alloy with advanced physicomechanical properties was shown. The introduction of reinforcing TiB2 particles into an Inconel 625 matrix was confirmed to increase the microhardness and tensile strength of the material obtained. Apparently, the composite structure of the samples facilitates the realisation of several strengthening mechanisms: (1) a grain boundary mechanism that causes strengthening and dislocation movement; (2) a mechanism based on the grain structure breakdown and Hall–Petch relationship realisation.