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Рациональная фармакотерапия в кардиологии
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Рациональная фармакотерапия в кардиологии
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Рациональная фармакотерапия в кардиологии
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Рациональная фармакотерапия в кардиологии
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https://dx.doi.org/10.20996/18...
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LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2013Publisher:Silicea - PoligrafJournal:Rational Pharmacotherapy in Cardiology, volume 9, pages 532-541 (issn: 1819-6446, eissn: 2225-3653, Copyright policy )
Authors: O. I. Afanasieva; S. N. Pokrovsky;

doi: 10.20996/1819-6446-2013-9-5-532-541

LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY

Abstract

Antisense oligonucleotides (ASO) technology in elaboration of drugs for lipid metabolism correction is discussed. The main ASO types and modes of its action on the target mRNA are analyzed. Advantages and disadvantages of different ASO are considered in the context of requirements for their therapeutic applications.Methods of ASO chemical modification; advantages and disadvantages of different ways of ASO delivery into the cells; developments state of ASO-drugs for therapy of lipid metabolism disturbances; data from clinical trials of these drugs are described.

Keywords

lipid metabolism disturbances, нарушение липидного обмена, RM1-950, antisense therapy, cardiovascular disease, RC666-701, Diseases of the circulatory (Cardiovascular) system, Therapeutics. Pharmacology, антисенс-терапия, сердечно-сосудистые заболевания, antisense oligonucleotides, антисмысловые олигонуклеотиды

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    popularity
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    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Average
Average
gold
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