Keratotic Nodule on The Heel: A Quiz
Copyright policy )Keratotic Nodule on The Heel: A Quiz
A 51-year-old man, with a medical history of medullary thyroid carcinoma excised under thyroxine treatment presented with a painful enlarging lesion on his right heel since one year. A 3-cm diameter, greyish, infiltrated nodule with spicules was seen on physical examination (Fig. 1a). A 5-mm surgical excision was made and a total skin graft was used for reconstruction. Histopathology of the total resected tumour revealed pseudoepitheliomatous hyperplasic epidermis and a proliferation located between rete ridges, dermis and superficial hypodermis (Fig. 1b). The proliferation was composed of nets and cordons of cells with granular and abundant PAS-positive cytoplasm. Immunostains showed cytoplasmic positivity for s100 and inhibin (Fig. 1c). Three years later the patient is asymptomatic.
Male, Skin Neoplasms, Biopsy, Medical Subject Headings::Diseases::Neoplasms, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Pumps::Symporters::Norepinephrine Plasma Membrane Transport Proteins, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination, Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Inhibins, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid Hormones::Thyroxine, Medical Subject Headings::Anatomy::Body Regions::Extremities::Lower Extremity::Foot::Heel, Biomarkers, Tumor, Humans, Medical Subject Headings::Anatomy::Integumentary System::Skin, Skin, Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Subcutaneous Tissue, Giant Cell Tumors, Keratosis, Middle Aged, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Muscle Tissue::Granular Cell Tumor, Immunohistochemistry, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Tissue Transplantation::Skin Transplantation, Medical Subject Headings::Anatomy::Integumentary System::Skin::Dermis, Heel
Male, Skin Neoplasms, Biopsy, Medical Subject Headings::Diseases::Neoplasms, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Pumps::Symporters::Norepinephrine Plasma Membrane Transport Proteins, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination, Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Inhibins, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid Hormones::Thyroxine, Medical Subject Headings::Anatomy::Body Regions::Extremities::Lower Extremity::Foot::Heel, Biomarkers, Tumor, Humans, Medical Subject Headings::Anatomy::Integumentary System::Skin, Skin, Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Subcutaneous Tissue, Giant Cell Tumors, Keratosis, Middle Aged, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Muscle Tissue::Granular Cell Tumor, Immunohistochemistry, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Tissue Transplantation::Skin Transplantation, Medical Subject Headings::Anatomy::Integumentary System::Skin::Dermis, Heel
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