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Article . 2017
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Russian Journal of Genetics Applied Research
Article . 2017 . Peer-reviewed
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https://dx.doi.org/10.1134/s20...
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Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2017 Russian Federation English Publisher:Pleiades Publishing LtdJournal:Russian Journal of Genetics: Applied Research, volume 7, pages 191-194 (issn: 2079-0597, eissn: 2079-0600, Copyright policy )
Authors: Voronova, O. L.; Fedorova, E. P.; Filonova, M. V.; Ermolaeva, L. A.; Fomina, T. I; Churin, A. A.; Neupokoeva, O. V.;

doi: 10.1134/s2079059717020095

Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis

Abstract

The gene protection effects of the hairy transgenic root extract, obtained as a result of the transformation of Scutellaria baicalensis into Agrobacterium rhizogenes, were revealed on a model of paclitaxel induced genotoxicity in mouse bone marrow and the Drosophila melanogaster somatic cells both under acute and chronic administration at the early and late periods of the study. The stimulation of granylocyto- and erythrocytopoiesis was demonstrated for the hairy roots extract of Scutellaria baicalensis on a rat model of paclitaxel- induced myelosuppression.

Country
Russian Federation
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Keywords

миелосупрессия, миелотоксичность, шлемник байкальский, паклитаксел

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green