Molecular mechanisms of lymphocyte apoptosis injury in chronic viral infection

Name: Molecular mechanisms of lymphocyte apoptosis injury in chronic viral infection
Creator: O. B. Zhoukova
Keywords: 0301 basic medicine, 0303 health sciences, мембранный потенциал митохондрий, хроническая вирусная инфекция, tnf-рецептор, apoptosis, R, tnf-receptor, lymphocyte, fas-receptor

O. B. Zhoukova

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Article . 2006 . Peer-reviewed

License: https://bulletin.tomsk.ru/jour/about/editorialPolicies#openAccessPolicy

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Бюллетень сибирской медицины

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License: CC BY

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Бюллетень сибирской медицины

Article . 2006

Data sources: DOAJ

https://dx.doi.org/10.20538/16...

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Molecular mechanisms of lymphocyte apoptosis injury in chronic viral infection

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 30 Sep 2006Publisher:Siberian State Medical UniversityJournal:Bulletin of Siberian Medicine, volume 5, pages 19-25 (issn: 1682-0363, eissn: 1819-3684,

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Authors: O. B. Zhoukova;

doi: 10.20538/1682-0363-2006-3-19-25

Molecular mechanisms of lymphocyte apoptosis injury in chronic viral infection

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Abstract

Programmed cell death of lymphocytes in patients with chronic infections induced by tick-borne encephalitis, hepatites B and C was investigated. The injury character in realization of lymphocyte apoptosis is shown to depend on molecular features of the infectious agent. Apoptotic death of lymphocytes was elevated after their incubation in vitro with dexamethazone, etopozide and in the environment without serum. Receptor-dependent and mitochondrial paths of apoptotic signal conduction ways are preferably modulated in chronic virus persistence.

Keywords

мембранный потенциал митохондрий, хроническая вирусная инфекция, tnf-рецептор, apoptosis, R, tnf-receptor, lymphocyte, fas-receptor, mitochondrial membrane potential, лимфоцит, апоптоз, Medicine, fas-рецептор, chronic viral infection

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