The operation to close a ventricular septal defect with an occluder is a minimally invasive procedure performed through a transvascular approach. The occluder is introduced via the femoral vein or artery and transported to the site of the defect, where it is deployed to close the hole in the ventricular septum, preventing pathological blood shunting. The advantage of this technique is its minimal invasiveness, rapid patient recovery, and reduced risk of complications compared to open surgery. This article presents a clinical case of successful treatment of this pathology, confirming the importance of timely intervention in post-infarction ventricular septal rupture to improve patient’s survival and functional status. The minimally invasive closure of the defect with an occluder, used in this case, proved effective in stabilizing the patient with Dressler syndrome and subsequent preparing for coronary artery bypass grafting.