Respiratory symptoms do not reflect functional impairment in early CF lung disease
Copyright policy )Respiratory symptoms do not reflect functional impairment in early CF lung disease
Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known.We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life.We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms.We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone.
- University of Zurich Switzerland
- University Children’s Hospital Basel Switzerland
- Boston Children's Hospital United States
- University Hospital of Bern Switzerland
- University Children's Hospital Zurich Switzerland
Male, Cystic Fibrosis, Infant, 610 Medicine & health, Respiratory Function Tests, Respiratory Rate, 10036 Medical Clinic, 2740 Pulmonary and Respiratory Medicine, 360 Social problems & social services, Predictive Value of Tests, Case-Control Studies, Humans, Female, 2735 Pediatrics, Perinatology and Child Health, Prospective Studies, Case-Control Studies; Cystic Fibrosis/physiopathology; Female; Humans; Infant; Male; Predictive Value of Tests; Prospective Studies; Respiratory Function Tests; Respiratory Rate; Cohort study; Cystic fibrosis; Healthy controls; Infancy; Respiratory symptoms
Male, Cystic Fibrosis, Infant, 610 Medicine & health, Respiratory Function Tests, Respiratory Rate, 10036 Medical Clinic, 2740 Pulmonary and Respiratory Medicine, 360 Social problems & social services, Predictive Value of Tests, Case-Control Studies, Humans, Female, 2735 Pediatrics, Perinatology and Child Health, Prospective Studies, Case-Control Studies; Cystic Fibrosis/physiopathology; Female; Humans; Infant; Male; Predictive Value of Tests; Prospective Studies; Respiratory Function Tests; Respiratory Rate; Cohort study; Cystic fibrosis; Healthy controls; Infancy; Respiratory symptoms
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!