In modern conditions, the weight of the contribution of stress-induced states to the morbidity and mortality of the population increases, which determines the relevance of assessing the indicators of psycho-emotional status and the level of adaptation of adolescents living in an ecocrisis region. Materials and methods. A scientific research of the indicators of psychoemotional status and the level of adaptation of 269 adolescents (117 girls and 92 boys) aged 14 to 16 years living in an ecocrisis region are described. Results. 22.6 % of the examined adolescents showed a high probability of neurotization, 37.7 % of adolescents had high situational anxiety, 32.6 % had high personal anxiety, and 23.6 % of the examined were diagnosed with neuropsychiatric disadaptation syndrome. Conclusions. The direct correlation dependence of maladaptation with situational (r = 0.32) and personal (r = 0.21) anxiety are established. The results that we have got obtained necessitate the development of a program to correct violations of psychoemotional status and increase the adaptive capabilities of adolescents living in an ecocrisis region.