Introduction: infectious endophthalmitis is a marked inflammation of the intraocular fluids and tissues due to the invasion and the replication of microorganisms inside the ocular structures that causes a significant loss of visual acuity. Objective: to know the incidence of postoperative endophthalmitis in a period of time. Method: a cross-sectional descriptive observational study was performed in patients undergoing intraocular surgical intervention at Villa Clara Ophthalmological Center in the period between 2015 and 2017. The rates of endophthalmitis incidence were calculated for each intraocular surgery type. Results: the general postoperative endophthalmitis incidence was 0.17%; 86.7% of the cases were subsequent to the cataract operation, with an 0.16% incidence; decreased vision, conjunctival cilia hyperemia and loss of the reddish-orange back reflex occurred in 100% of patients; in 73.3% of the cases, the endophthalmitis was acute and the etiological agent could be isolated in 40% of them and the most frequent germ was Serratia. As part of the intraocular treatment performed in 40% of the patients intravitreal antibiotics were applied and they were sent to the tertiary center for early pars plana vitrectomy, this behavior was the most adopted in the last year. Conclusions: postoperative endophthalmitis incidences, and specifically post-cataract operation found in this study, were similar to those reported in other investigations.