Grapevine is one of the most important culture grown in the world. It is attacked by a large number of phytopathogenic fungi, of which species of the family Botryosphaeriaceae pose one of the most significant threats. Symptoms occur in the form of necrotic lesions, rot of fruits and decline of branches. The disease is more often observed in older vineyards. The most important preventive measures include planting a healthy planting material and the choice of a suitable location for cultivation, and the most important protection measures include the removal of infected remains from the vineyards and their destruction, the application of fungicides, the coating of wounds after pruning, and the application of biological preparations for plant protection.