Based on the orifice cavitation device as the research object, and the motion equation of spherical cavitation is derived; the gas holdup changes caused by the gas-liquid two-phase mass transfer, fluid inflow and outflow control volume are taken into consideration, and the orifice cavitation is derived. The change equation of fluid gas holdup in the vessel, based on the cavitation model, the bubble distribution, pressure and velocity characteristics of the transient cavitation in the orifice channel within 100ms are obtained through numerical simulation with a time step of 10-5s. Establishing a radial section in the orifice channel and using the gas volume flow rate distribution to further prove the stability of the fluid cavitation state. Through simulation and experiment, the influence of two different flow crosssectional area orifice structures on the cavitation effect under different pressure differences is verified. The results show that the cavitation effect can be measured by the volume flow rate of the gas phase. Increasing the number of orifice channels can affect the cavitation effect more than changing the pore diameter.