The aim of this study was to determine the relationships between coping with stress, intolerance to uncertainty and automatic thoughts. The research sample consists of 393 (Male: 194, Female: 199) volunteer participants living in Central Anatolia. The research data were collected using the Stress Coping Styles Scale, Intolerance to Uncertainty Scale, Automatic Thoughts Scale and a personal information form developed by the researcher. Significant relationships were found between intolerance to uncertainty, automatic thoughts and sub-dimensions of coping with stress (self-confident, helpless style, optimistic, submissive, seeking social support). In the regression analysis, it was determined that coping with stress and automatic thoughts predicted intolerance to uncertainty. To protect mental health, based on the results of this study, trainings can be organized to teach positive stress coping mechanisms and to identify negative automatic thoughts that predict intolerance to uncertainty in individuals. Individuals who have problems with these issues can be included in psycho-educational group practices.