Redução dos linfócitos T-CD8+ citotóxicos observada com a terapia Puva em paciente com vitiligo Reduction of cytotoxic T-CD8+ lymphocytes observed during PUVA therapy in a patient with vitiligo

Daniela Pereira Antelo; Absalom Lima Filgueira; José Marcos Telles da Cunha

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Article . 2008

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Redução dos linfócitos T-CD8+ citotóxicos observada com a terapia Puva em paciente com vitiligo Reduction of cytotoxic T-CD8+ lymphocytes observed during PUVA therapy in a patient with vitiligo

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2008 English Publisher:Sociedade Brasileira de DermatologiaJournal:Anais Brasileiros de Dermatologia (issn: 0365-0596,

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Authors: Daniela Pereira Antelo; Absalom Lima Filgueira; José Marcos Telles da Cunha;

Redução dos linfócitos T-CD8+ citotóxicos observada com a terapia Puva em paciente com vitiligo Reduction of cytotoxic T-CD8+ lymphocytes observed during PUVA therapy in a patient with vitiligo

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Abstract

Na patogênese do vitiligo tem-se enfatizado o papel das células T citotóxicas. Identificadas pelo antígeno linfocitário cutâneo (CLA), essas células já foram descritas no sangue de pacientes com outras dermatoses e podem ser depletadas pela fototerapia concomitantemente à melhora clínica. Descreve-se caso de vitiligo generalizado com melhora clínica expressiva após Puva, no qual houve redução de 25% dos linfócitos T CD8+-CLA+ circulantes.The role of cytotoxic T cells (CD8+) has been emphasized in the pathogenesis of vitiligo. This cell population, identified by a skin homing molecule (cutaneous lymphocyte associated antigen Â- CLA), has been described in patients with other dermatoses and can be reduced with phototherapy. The authors present the case of a patient with generalized vitiligo and clinical recovery after PUVA parallel to a 25% reduction in CD8+-CLA+ T cells in the peripheral blood.

Keywords

PUVA therapy, Imunofenotipagem, RL1-803, Vitiligo, Dermatology, Terapia Puva, Immunophenotyping

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