Current follow-up studies of patients after pulmonary embolism (PE) show a high rate of recurrence of venous thromboembolism (VTE) during the first year after the initial episode. The most significant reason for relapse is the refusal to take anticoagulants in the first six months after PE, while the fear of significant bleeding is the main reason for not continuing anticoagulant therapy in the presence of an average and high risk of VTE recurrence. In real clinical practice, a standard coagulogram is used as a control of hemostasis, which cannot help in identifying the threat of a thrombotic state. This article describes a clinical case of effective control of plasma hemostasis against the background of prolonged anticoagulant therapy using the method of thrombodynamics, which also demonstrates plasma hypercoagulation during the period of anticoagulant withdrawal.