The goal is to develop methodological approaches to monitoring pharmacoprophylactic measures for the development of myocardial infarction based on the assessment and prediction of psychosocial risk factors. Material and methods. The object of the study is patients with a diagnosis of myocardial infarction, hospitalized in specialized cardiological departments of the city of Kemerovo. As primary documentation, the study used data from a questionnaire survey of 360 patients with myocardial infarction, conducted for a comprehensive study of this problem. The following research methods were used: content analysis, information and analytical, marketing, sociological (questionnaire survey), mathematical and statistical. Results. A methodological approach to monitoring pharmacoprophylactic measures based on the assessment and prediction of psychosocial risk factors has been developed. The structure of prognostic tables for use by medical specialists during periodic and targeted preventive examinations has been determined. The most vulnerable groups of people, especially those at risk of pathological risk, although they do not have pronounced signs of the disease, have been identified. Conclusion. Achieving accessibility and improving the quality of medical and pharmaceutical care for patients with MI, along with conventional factors, psychosocial risk factors should be taken into account, which are also important predictors of the development of myocardial infarction, requiring the use of pharmacoprophylactic agents.