Isfahan, an ancient city in the center of the Iranian plateau, has had a thousand years of Islamic-Iranian urbanization. It has benefited from three prominent dynasties (Al-Buyeh, Seljuks, Safavid) Which peaked during the Safavid Era.One of the large features of urbanization during this period was the Isfahan “urban economics" development which the various factors have contributed to its realization. In this research, the role of indicators of "urban economy" components such as 'population', 'transport infrastructure' and 'location', are examined.In this regard, the question is as to What factors influenced on these indicators and What role did these indicators play in the development of the Isfahan Urban Economy Organization?The current study is historical research that has been conducted by a descriptive-analytical method.The research results show that factors such as "population density", "development of transportation infrastructure" and "proper location of urban elements" have had a significant impact on the development of Isfahan's "urban economics".