The skeletal striated muscle is one of the main tissues capable of regulating glycemia, increasing glucose transport by both insulin stimulation and physical exercise. About insulin, it has been widely shown that must contact and activate its receptor, triggering an important signaling cascade in which modulators such as IRS, PI3K, Akt, AS160 (TBC1D4), etc, take part. Regarding the activation triggered by physical exercise, so far, the signaling pathways elucidated have been shown to be essential in this process. Among the most studied proteins and pathways we have: activation of the AMP 5ʹ-activated protein kinase (AMPK), calcium-sensing proteins (CaMKK, CaMKII, and PKC), which in turn change their phosphorylation state after exercise, and a stretch-sensitive related-proteins (Rac1, PAK).