ENGLISH ABSTRACT: During the first COVID-19 lockdown, public health officials and political decision makers were aware that the lockdown would have some sort of psychological repercussion, but it was totally unknown what reactions the disease would evoke. This article investigates how the physical and mental health (well-being) were affected. Data from the COVID-19 survey indicate that negative consequences were uneven distributed in the population with especially young women, but also young men reporting alarming degrees of low well-being. DANSK RESUMÉ: Gennem første COVID-19 nedlukning i foråret 2020 var det endnu helt ukendt, hvilke reaktioner sygdommen ville fremkalde. Denne artikel undersøger, hvordan det fysiske og psykiske helbred (trivslen) blev påvirket. Den fremhæver, hvordan især de negative påvirkninger ramte befolkningen skævt, og at særligt de unge kvinder, men også unge mænd rapporterede mistrivsel i alarmerende omfang.