Object of the research (observation). Mortality rate of the population from the diseases of endocrine system. Purpose of the research – to study basic tendencies of mortality rate from the diseases of endocrine system in the Altai Krai within the last 5 years. Research methods. Statistic, analytic. Basic results. The analysis has shown that considerable changes of mortality rate from diabetes mellitus characterized by maximum increase among the persons aged over 70 years old are being observed. Field of their application. Organization of medical activity. Conclusions. Within the years 2012-2016 in Altai Krai, intensive growth of mortality rate from the diseases of endocrine system due to the growth of mortality rate by from diabetes mellitus is being observed, which to a certain extent results from the changes of the approaches in the definition of the basic reason of death.