We present the results of a search for photometric variable blue straggler stars (BSSs) in the globular cluster M53. Six of the 151 probable BSSs are identified as variable candidates based on the robust variable star detection technique of Welch & Stetson (1993). Most variable BSS candidates appear to occupy the instability strip in the color-magnitude diagram, and they appear to have visual light amplitudes of 0.2 mag - 0.3 mag. Further observations are required, however, to resolve the nature of variability between pulsating stars and eclipsing binaries for these variable BSS candidates.