Background and Objective: Couple burnout is phenomenon which affects many couples. It is the main cause of emotional divorce, and it can provide a ground for formal divorce of couples. This study was conducted to evaluate the effectiveness of stress inoculation training (SIT) on reducing couple burnout among married women. Methods: This quasi-experimental study was performed on 30 married women whom refered to Aram psychological and counseling service center in Gorgan, norhern Iran during 2016. The subjects selected by available sampling method and were assigned into intervention and control groups via a non-randomized method. Subjects in intervention group were received the stress inoculation training intervention in eight 2-hour session in groups (one session per week). The control group did not receive intervention until the end of the follow up stage. The data gathering tool was Couple Burnout Measure of Pinez (1996) which was completed by all subjects in pre-test, post-test and one-month follow up. Results: After treatment and one-month follow up, the stress inoculation training intervention was effective on reducing couple burnout and its components including physical fatigue, mental fatigue, and emotional fatigue (P<0.05). Conclusion: Stress inoculation training reduces couple burnout and its components in married women. Therfore, stress inoculation training recommends to be an appropriate interventional option for reducing marital problems and improving couple relationships.