Background: Iodine is the essential component for synthesis of tyroid. In the area of dificiency iodium the iodine intake was also obtained from high doses of iodine capsules and iodized salt. While in the area of non-iodine deficiency, iodine source may be more complex, considering a more varied diet and a lot of drugs containing iodine. The Wayne index used to estimate the suspect of hyperthyroidism but to get right diagnosis for hyperthyroidism are use laboratory examination. Positiv hyperthyroidsm if TSH in serum < 0,3 µlU/ml and FT4 > 2 nano gram/dl. Obyektives: The purpose of this paper is to view clinical characteristic in the nonendemik areas and endemic iodine deficiency disorder. Method: The method used is analitic research design with a crosssectional study. Respondent of the research are woman that age 15-50 years old. The number of samples in this research is 36 woman from endemic areas and 36 samples from non endemic areas. Analysis of data using excel and SPSS programs. Result: Results can be seen that in general clinical characteristics in two areas namely endemic and non endemic areas are not statistically different with p = 0.803 (p> 0.05). But in these two regions are typical symptoms of hyperthyroidism suspect in non-endemic area when compared with endemic areas such as the prominent and showed statistical differences in the symptoms exopthalmus value of p = 0.00, rapid pulse value p = 0.01, appetite increased with p-value = 0.03. alue index of sensitivity and specificity to predict hyperthyroid wayne in endemic areas is 0.67 and Se 0.87. While the value of sensitivity and specificity indices wayne to suspect hyperthyroidism in non-endemic areas is 0.55 and 0.925Se. Keywords: hyperthyroidism, endemic, non endemic, clinical characteristics