Background and Aims: Work related musculoskeletal disorders are common in midwiferypractice which requires extensive labor-intensive tasks. Therefore midwives are prone tomusculoskeletal disorders. This study aims at investigating the risk factors and musculoskeletalsymptoms among in midwives.Method: we conducted this cross-sectional study in Hamedan, western Iran. Active Midwives(n=134) were asked to complete the questionnaires (demographic and a version of the Nordicquestionnaire) if they had at least 1 year experience in practice and were not pregnant during theprevious year. 102 Midwives completed the questionnaires. Data were analysed by SPSS v.10software.Results: 66.7% of the Midwives reported some musculoskeletal symptoms, of whom 54% waswork related. The most common musculoskeletal symptoms were low back pain (50%), shouldersand wrists (46%). There were significant associations between musculoskeletal symptoms andmarital status (p< 0.001), duration of employment (p<0.02), shift work (p<0.0001), work place(p<0.002) and hours per month spent for performing tasks (p<0.01). However, there was nosignificant association between the symptoms and age, BMI, and the number of childbirth. 51.9%of Midwives required treatment, 33.3% missed work for seven days or more and 22.2% changedtheir work place.Conclusion: These findings indicate that midwives require more in-service training about theirposture to reduce the prevalence of work- related symptoms and improve their overallperformance.