
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood, several theories have been suggested including direct and indirect pathways induced by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route. Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells. Nevertheless, the indirect mechanisms, including blood-clotting abnormalities and prolonged activation of the immune system, can result in further tissue and organ damages seen during the course of the disease. This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.
autoantibodies, encephalitis, COVID-19, renin-angiotensin system, Review, coagulopathy, neuroinflammation, viral encephalopathy, Neurology. Diseases of the nervous system, CNS infection, autoantibodies; cns infection; coagulopathy; covid-19; encephalitis; neuroinflammation; renin-angiotensin system; viral encephalopathy, RC346-429
autoantibodies, encephalitis, COVID-19, renin-angiotensin system, Review, coagulopathy, neuroinflammation, viral encephalopathy, Neurology. Diseases of the nervous system, CNS infection, autoantibodies; cns infection; coagulopathy; covid-19; encephalitis; neuroinflammation; renin-angiotensin system; viral encephalopathy, RC346-429
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 48 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 1% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 1% |
