Lymphatic filariasis (LF) is still a public health problem in Indonesia, particularly in rural area. Untill 2009, there were 186 LF cases reported from South Sumatera. LF is a chronic disease that caused by the infection of filariae worm and transmitted by various species of mosquitoes. LF that caused by B. malayi is not only infect human but also animal, such as crab-eating macaque (Macaca fascicularis), silvered leaf monkey (Presbythis cristatus), and cat (Felis catus). A study was conducted in order to know the reservoir and vector of malayi filariasis in Muara Padang village, Muara padang sub-district, Banyuasin district, South Sumatera. This was a cross-sectional study where data were collected through reservoir blood examination (cat) and finding microfilariae L3 form in mosquito. The results showed that mo microfilariae of B. Malayi was found in 17 blood samples of cat. Instead of B. malayi, Dirofilaria repens, a type of animal filarial, was found in 11 blood samples of cat. Moreover, there was no microfilariae L3 form in 701 mosquitoes.