The search for information was carried out in the PubMed, Scopus, Webof-science, RSCI databases using the following keywords: post-embolization syndrome, uterine artery embolization, uterine myoma, without language restrictions. For analysis, 50 sources with full access to the text were selected, 90 % of which were published within the last five years, and 50 % within the last three years. The criteria for excluding sources were low information content and outdated data. Post-embolization syndrome (PES) after uterine artery embolization (UAE) in uterine myoma is an early postoperative complication that develops in the first 24-48 hours after the procedure and usually resolves spontaneously within 10-14 days. The frequency of PES has not been precisely established today, therefore it is in a wide range: from 0.2 % to 96 %. Prevention and treatment of PES consists of intraoperative and postoperative symptomatic treatment of the symptoms of the complication. Different strategies are used – intra-arterial intraoperative administration of anesthetics, the appointment of non-steroidal anti-inflammatory drugs, paracetamol and opioids. It should be noted that recommendations regarding the prevention and treatment of severe PES in UAE are based on low-quality studies with insufficient follow-up. In the strategy to combat PES, further large randomized clinical trials are needed to create unified approaches based on evidence-based medicine.