The rapid development of 5G technology has brought a digital technology revolution that puts forward higher requirements for the spread of earthquake prevention and disaster reduction information, and also provides new development opportunities. As an important task at the national strategic level, earthquake prevention and disaster reduction are not only related to reality people’s livelihood, but also affect the stability of social order. Its science popularization propaganda activities and knowledge content need more diversified communication methods. The public’s attention to science popularization work and knowledge also presents a growth trend of index level. Based on the analysis of existing science popularization communication forms, we think about how 5G technology can help the communication contents, forms, media and ideas of science popularization publicity activities for earthquake prevention and disaster reduction, as so to inject vitality and propose feasibility countermeasures for science popularization publicity activities of earthquake prevention and disaster reduction.