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Aktualʹnaâ Infektologiâ
Article . 2016
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Chemotheraphy Efficiency of Phosphonium Heterocyclic Compounds with Pyrimidine Cycle in Models of Generalized Staph Infection

Authors: Humenna, A.V.;

Chemotheraphy Efficiency of Phosphonium Heterocyclic Compounds with Pyrimidine Cycle in Models of Generalized Staph Infection

Abstract

Проведено изучение химиотерапевтической эффективности 2-фенил-4-(1-пиролидинил)-6-изопропилтио-5-пиримидилтрифенилфосфоний перхлората, который относится к гетероциклическим фосфониевым соединениям с пиримидиновым циклом, в эксперименте на модели генерализованной стафилококковой инфекции. Получены положительные результаты, которые дадут право делать вывод о возможности их использования в клинических исследованиях и создания на их основе перспективных антибактериальных и антисептических препаратов.

It was conducted the study of the effectiveness of chemotherapy with 2-phenyl-4-(1-pyrrolidinyl)-6-izopropiltio-5-pyrimidyltriphenylphosphonium perchlorate, which refers to phosphonium heterocyclic compounds with pyrimidine cycle in the experiment on the model of generalized staph infection. The results were positive and they allow make a conclusion about the possibility of their use in clinical trials and develop promising antibacterial and antiseptic preparations on their basis.

Проведено вивчення хіміотерапевтичної ефективності 2-феніл-4-(1-піролідиніл)-6-ізопропілтіо-5-піримідилтрифенілфосфоній перхлорату, яка відноситься до гетероциклічних фосфонієвих сполук з піримідиновим циклом, в експерименті на моделі генералізованої стафілококової інфекції. Отримано позитивні результати, що дадуть право робити висновок про можливість використання їх у клінічних дослідженнях і створення на їх основі перспективних антибактеріальних та антисептичних препаратів.

Keywords

генерализованная стафилококковая инфекция; химиотерапевтическая эффективность; четвертичные фосфониевые соединения; гетероциклические фосфониевые соединения, chemotherapy effectiveness, generalized staphylococcal infection, heterocyclic phosphonium compounds, quaternary phosphonium compounds, Infectious and parasitic diseases, RC109-216, generalized staphylococcal infection; chemotherapy effectiveness; quaternary phosphonium compounds; heterocyclic phosphonium compounds, генералізована стафілококова інфекція; хіміотерапевтична ефективність; четвертинні фосфонієві сполуки; гетероциклічні фосфонієві сполуки

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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