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PARTICULARITĂȚILE CLINICO-HEMODINAMICE ALE PACIENȚILOR CU INFARCT MIOCARDIC ACUT CU ELEVAREA SEGMENTULUI ST SUPUȘI TRATAMENTULUI INTERVENȚIONAL TARDIV

Authors: Abraş, M.D.; Surev, A.I.; Esanu, A.; Grib, A.L.; Vreme, C.;

PARTICULARITĂȚILE CLINICO-HEMODINAMICE ALE PACIENȚILOR CU INFARCT MIOCARDIC ACUT CU ELEVAREA SEGMENTULUI ST SUPUȘI TRATAMENTULUI INTERVENȚIONAL TARDIV

Abstract

Для сохранения жизнеспособности миокарда у больного с острым инфарктом миокарда с подъемом сегмента ST и улучшения выживаемости необходимо как можно быстрее восстановить коронарный кровоток, лучше всего в течение первых 12 часов. Актуальной дилеммой интервенционных кардиологов является решение вопроса о возможности выполнения интервенционной реперфузии миокарда у больных с отсроченным обращением более 12 часов от начала заболевания и установление прогностических факторов выполняемых у данной категории больных интервенционных вмешательств. В исследование были включены 63 пациента с с острым инфарктом миокарда с подъемом сегмента ST, разделенные на 2 группы: в первую вошли 33 пациента, поступивших в отделение неотложной помощи в течение первых 12 часов от начала заболевания, во вторую группу вошли 30 пациентов, у которых первый медицинский контакт был более чем через 12 часов после появления симптомов. Группы сравнивались между собой по хорошо определенным критериям. Первичными конечными точками end points были оценка больших сердечно-сосудистых событий MACE, а также ремоделирования/обратного ремоделирования миокарда желудочков и предикторы интервенционных процедур. Улучшение сократительной функции миокарда левого желудочка ФВЛЖ, по-видимому, связано с ранней реваскуляризацией миокарда. Раннее обращение больных с острым инфарктом миокарда с подъемом сегмента ST можно рассматривать как независимый предиктор улучшения кинетики миокарда левого желудочка, вызванной острой ишемией миокарда. Сократительная функция миокарда, представленная фракцией выброса, считается независимым предиктором отдаленной и краткосрочной смертности у больных с острым инфарктом миокарда с подъемом сегмента ST. Предварительные результаты исследования подчеркивают практическую ценность интервенционных процедур также у пациентов с поздним обращением - более 12 часов от начала заболевания и первого медицинского контакта.

To save the viability of the ischemic myocardium in a patient with ST-segment elevation myocardial infarction and improve the survival, coronary blood flow must be restored as soon as possible, preferably within the first 12 hours after the onset of pain. The current dilemma of interventional cardiologists is the decision about the possibility of performing interventional myocardial reperfusion in the patients with delayed presentation more than 12 hours from the onset and establishing the predictive factors of the procedures performed in this category of patients. In ths study 63 patients with STEMI were included, divided into 2 groups: the first one included 33 patients presentetd at the emergency department within the first 12 hours after the onset of STEMI, and the second group consited of 30 subjects with STEMI in whom the first medical contact was more than 12 hours after the onset of symptoms. The groups were compared with each other according to the well-established criteria. The primary end points were the assessment of major cardiovascular events MACE, as well of ventricular myocardium remodeling/reverse-remodeling and predictors of interventional procedures. The improvement of left ventricular myocardial contractile function LVEF, seems to be associated with early myocardial revascularization. Early presentation in STEMI can be considered an independent predictor of the improvement of the regional kinetics affected by AMI. The contractile function of the LV myocardium represented by the ejection fraction is considered an independent predictor of long-term and short-term mortality in patients with STEMI. The preliminary results of the research highlight the applicative value of PCI procedures also for patients with delayed presentation - more than 12 hours from the onset of the disease and the first medical contact.

Pentru a salva viabilitatea miocardului ischemizat la un pacient cu infarct miocardic acut cu supradenivelarea de segment ST și pentru a îmbunătăți supraviețuirea, fluxul sanguin coronarian trebuie restabilit cât mai curând posibil, de preferință în primele 12 ore de la debutul bolii. Dilema actuală a cardiologilor intervenţionişti este decizia cu privire la posibilitatea efectuării reperfuziei miocardice intervenţionale la pacienţii cu prezentare întârziată mai mult de 12 ore de la debut şi stabilirea factorilor predictivi ai procedurilor efectuate la această categorie de pacienţi. În acest studiu au fost incluși 63 de pacienți cu STEMI, împărțiți în 2 grupe: primul a inclus 33 de pacienți prezentați la serviciul de urgență în primele 12 ore de la debutul STEMI, iar al doilea grup a fost format din 30 de subiecți cu STEMI la care primul contact medical a fost la mai mult de 12 ore de la apariția durerilor. Grupurile au fost comparate între ele conform criteriilor bine stabilite. Obiectivele principale au fost evaluarea evenimentelor cardiovasculare majore MACE, remodelarării/ invers-remodelării miocardului ventricular și predictorii procedurilor intervenționale. Îmbunătățirea funcției contractile miocardice a ventriculului stâng FEVS pare să fie asociată cu revascularizarea miocardică precoce. Prezentarea precoce în STEMI poate fi considerată un predictor independent al îmbunătățirii cineticii regionale afectate de IMA. Funcția contractilă a miocardului VS reprezentată de fracția de ejecție este considerată un predictor independent al mortalității pe termen lung și pe termen scurt la pacienții cu STEMI. Rezultatele preliminare ale cercetării evidențiază valoarea aplicativă a procedurilor PCI și pentru pacienții cu prezentare întârziată - peste 12 ore de la debutul bolii și primului contact medical.

Related Organizations
Keywords

Medicine (General), evenimente cardiovasculare majore, infarct miocardic acut cu supradenivelarea segmentului ST, major cardiovascular events, infarct miocardic acut cu supradenivelarea segmentului st, большие сердечно-сосудистые события, RC31-1245, ST-segment elevation myocardial infarction, ранняя и поздняя интервенционная реперфузия миокарда, Other systems of medicine, R5-920, инфаркт миокарда с подъемом сегмента ST, revascularizare miocardică intervențională precoce și tardivă, Public aspects of medicine, RA1-1270, Internal medicine, early and late myocardial intervențional reperfusion, RZ201-999

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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