Microwave reactions of 2, 5-bis-trifluoromethyl-1, 3, 4-oxadiazole with norbornenes
Microwave reactions of 2, 5-bis-trifluoromethyl-1, 3, 4-oxadiazole with norbornenes
The reactions of 2, 5-bis-trifluoromethyl-1, 3, 4- oxadiazole 2 with norbornenes [1] under microwave conditions were investigated. MW reactions enabled the reaction times and temperatures to be significantly reduced, as compared to classical thermal reactions. Furthermore, unprecedented stereochemical outcome of the reaction with 7- oxanorbornenes 1 was found, where linear product 4 was isolated, alongside usual bent-shaped cycloadduct 3 [2]. The reaction mechanism was investigated computationally by density functional methods (B3LYP/6-31G*), and stereochemical results explained by stereoelectronic reasons [3]. [1] R. N. Warrener, D. Margetić, R. A. Russell, Synlett (1998) 585. [2] R. N. Warrener, Eur. J. Org. Chem. (2000) 3363. [3] D. Margetić, R. N. Warrener, Croat. Chem. Acta. 76 (2003) 357.
quantum chemical calculations, microwave reactions; cycloadditions; quantum chemical calculations, microwave reactions, cycloadditions
quantum chemical calculations, microwave reactions; cycloadditions; quantum chemical calculations, microwave reactions, cycloadditions
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!