Етанольний екстракт трави Dracocephalum moldavica L., вирощеної в умовах Житомирського Полісся, характеризується антимікробною активністю стосовно тест-культур мікроорганізмів – гриба Candida albicans, грам-позитивних (Staphylococcus aureus) та грам-негативних (Escherichia coli) бактерій. На Pseudomonas aeruginosa екстраговані речовини не впливали. The paper investigates the biological activity of 40 % ethanol extract of Moldavian dragonhead herb grown under the conditions of Ukrainian Polissya as to golden staphylococcus (Staphylococcus aureus), coliform bacillus Escherichia coli, Pseudomonas aeruginosa and Candida albicans which are pathogenic in reference to other organisms. It has been shown that the extract of the herb D. moldavica was characterized by antimicrobial activity since extracted substances doubled the indices of minimal bacteriostatic and minimal bactericidal concentrations of ethanol extract S. aureus. Concerning C. albicans, the index of minimal bacteriostatic concentration increased two-fold. The activity of these substances with respect to E. coli was characterized by the doubled intensification of bactericidal effect. The extracted substances did not influence P. aeruginosa. The paper draws attention to the prospects of the further more detailed study of ethanol extracts of Moldavian dragonhead with the aim of producing antibacterial and antifungal herbal preparations.