Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ UPCommons. Portal de...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
versions View all 2 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

An Evolutionary Game Theory approach for a virus-defective particles-satellite system

Authors: Guaitoli, Sara Xiang Ru;

An Evolutionary Game Theory approach for a virus-defective particles-satellite system

Abstract

Wild-type (WT) viruses are the infectious forms of viruses mostly found in nature. They represent the standard form of the virus, capable of completing their full replication cycle within susceptible host cells. Viruses are known to replicate near the so-called ’critical mutation rate’, producing a cloud of mutations, including Defective Viral Genomes (DVG) as an unavoidable by-product of their error-prone replication. Defective Interfering (DI) particles are a subgroup of DVG, unable to self-replicating due to the lack of genomic fragments encoding the replication protein, and have been shown to interfere with the replication of the WT virus. Along with DI, other genetic elements known as Satellite (SAT) viruses, that are genetically distinct from the WT virus, can co-infect cells with the WT viruses and take advantage of viral proteins for their own benefit. The presence of the SAT viruses have effects that range from reduced symptom severity to enhanced virulence. The analysis of the population evolutionary dynamics involving these genetic elements is currently a highly active and promising area of research since engineered versions of DVG have been shown to act as antiviral agents. While interactions between WT viruses and DI have been widely studied, systems involving all three genetic elements remain less explored, despite their relevance in plant RNA viruses and biomedically relevant pathosystems like hepatitis B virus and its d SAT virus. This project studies the tripartite system under an Evolutionary Game Theory approach. We first analyse an existing model of cooperative behaviour among WT viruses, focusing on the emergence of defection strategies. Building on this, we introduce a new model that incorporates both DI and SAT viruses. Our analysis identifies a region in the strategy space where the SAT virus can persist in an evolutionarily stable manner. These findings offer a theoretical foundation for understanding the complex interaction between these viral elements and suggest potential directions for future research.

Related Organizations
Keywords

Àrees temàtiques de la UPC::Matemàtiques i estadística, Satellite viruses., Virus — Genètica, Public Goods Game, Viruses — Genetics, Evolutionary Stable Strategies, Classificació AMS::92 Biology and other natural sciences::92D Genetics and population dynamics, RNA Viruses, Classificació AMS::37 Dynamical systems and ergodic theory::37N Applications, Defective Interfering particles, Evolutionary Game Theory, Jocs, Teoria de, Theoretical Biology, Game theory

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average